By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
BeFirsTrankBeFirsTrank
  • Home
  • Car Reviews
  • Auto Shows
  • Bike Reviews
  • Future
  • New Car
  • Used Car
  • Contact Us !
Reading: Scientists Identify Antigens That May Trigger Type 1 Diabetes
Share
Aa
Aa
BeFirsTrankBeFirsTrank
  • Home
  • Car Reviews
  • Auto Shows
  • Bike Reviews
  • Future
  • New Car
  • Used Car
  • Contact Us !
Search
  • Home
  • Car Reviews
  • Auto Shows
  • Bike Reviews
  • Future
  • New Car
  • Used Car
  • Contact Us !
Have an existing account? Sign In
Follow US
© 2023 BeFirsTrank News Network
Future

Scientists Identify Antigens That May Trigger Type 1 Diabetes

srijita
Last updated: 2016/02/17 at 6:16 AM
By srijita 3 Min Read
Share
SHARE
Scientists Identify Antigens That May Trigger Type 1 Diabetes

When an autoreactive T cell sees its antigen, it becomes activated and can initiate disease. (Representational image)

New York:  A new class of antigens have been identified that may be a contributing factor to type 1 diabetes. Type-1 diabetes is the auto-immune form of diabetes, in which insulin-producing beta cells in the pancreas are destroyed by the body’s own immune cells, a study finds.

“Our lab studies the type of T cell known as a CD4 T cell,” said Kathryn Haskins from the University of Colorado School of Medicine in the US.

“We have focused on autoreactive CD4 T cells using a mouse model of autoimmune diabetes. We have been especially interested in identifying the antigens that activate these T cells,” Ms Haskins added in the paper published in journal Science.

Normally, a CD4 T cell is supposed to respond to “foreign” antigens. But in autoimmune disease the T cells respond to antigens that are generated in the body. Such proteins and peptides are called autoantigens.

When an autoreactive T cell sees its antigen, it becomes activated and can initiate disease. By identifying those antigens, scientists may be able to use that information to detect autoreactive T cells early in disease, or better yet, in at-risk individuals.

If they are able to use the antigens to turn off destructive T cells, they may be able to prevent the disease, the study finds.

Researchers conducted experiments to analyze the fractions of beta cells that contain antigen for autoreactive CD4 T cells in order to identify autoantigens in type 1 diabetes.

They discovered a new class of antigens that consist of insulin fragments fused to peptides of other proteins present in beta cells. That fusion leads to generation of hybrid insulin peptides that are not encoded in an individual’s genome.

If peptides in the body are modified from their original form, they essentially become “foreign” to the immune system and this may explain why they become targets for the autoreactive T cells.

The discovery of hybrid peptides as targets of the immune system provides a plausible explanation of how the immune system is tricked into destroying the body’s own beta cells. The discovery may also lead to a better understanding of other autoimmune diseases.

[“source-ndtv”]

You Might Also Like

India is at the forefront of the digital revolution

How the future will be altered by artificial intelligence

Cybersecurity audit: what it is and why you need one?

Personalized advertising fuels growth and drives competitiveness for European businesses

Personalization, AI, and the future of retail

TAGGED: 1, Antigens, Diabetes, Identify, May, Scientists, That, Trigger, Type
srijita February 17, 2016
Share
Previous Article 3D ‘Mini-Brains’ Developed In A US Lab
Next Article Finger Prick Blood Test May Help Detect Cancer

Calendar

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    

Latest Trending News

  • 4 Reasons to Buy a Used Car and Things to Keep in Mind August 2, 2025
  • India is at the forefront of the digital revolution August 1, 2025
  • Utilize the Advantages of Used Car Financing for Smart Investments July 30, 2025
  • Kia Sportage X-Line: Great SUV, Wrong Drivetrain July 28, 2025
  • Benefits of Purchasing a New Vehicle July 22, 2025
  • What is a Feature Article? June 27, 2025
  • The significance of independent reviews of balance bikes June 20, 2025

© 2023 Befirstrank News Network. All Rights Reserved.

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?